Protein Details: Amiloride-sensitive sodium channel subunit alpha

Protein ID

ICDB_Pro_0512

Protein Name

Amiloride-sensitive sodium channel subunit alpha

Gene Name

Scnn1a; Renac

Organism

Rattus norvegicus (Rat)

Length

698 amino acids

AlphaFoldDB

AF-P37089-F1-model_v4.pdb

Function

Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water; which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis; but also in airway surface liquid homeostasis; which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney; colon; lung and eccrine sweat glands. Also plays a role in taste perception (By similarity).

Sequence

MLDHTRAPELNIDLDLHASNSPKGSMKGNQFKEQDPCPPQPMQGLGKGDKREEQGLGPEPSAPRQPTEEEEALIEFHRSYRELFQFFCNNTTIHGAIRLVCSKHNRMKTAFWAVLWLCTFGMMYWQFALLFEEYLSYPVSLNINLNSDKLVFPAVTVCTLNPYRYTEIKEELEELDRITEQTLFDLYKYNSSYTRQAGARRRSSRDLLGAFPHPLQRLRTPPPPYSGRTARSGSSSVRDNNPQVDRKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINILSRLSDTSPALEEEALGNFIFTCRFNQAPCNQANYSKFHHPMYGNCYTFNDKNNSNLWMSSMPGVNNGLSLTLRTEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKEALDSLGGNYGDCTENGSDVPVKNLYPSKYTQQVCIHSCFQENMIKKCGCAYIFYPKPKGVEFCDYRKQSSWGYCYYKLQGAFSLDSLGCFSKCRKPCSVINYKLSAGYSRWPSVKSQDWIFEMLSLQNNYTINNKRNGVAKLNIFFKELNYKTNSESPSVTMVSLLSNLGSQWSLWFGSSVLSVVEMAELIFDLLVITLLMLLRRFRSRYWSPGRGARGAREVASTPASSFPSRFCPHPTSPPPSLPQQGMTPPLALTAPPPAYATLGPSAPPLDSAAPDCSACALAAL

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Detected in kidney; lung and testis (at protein level). In the testis; detected within the seminiferous tubules but not in the interstitial cells (at protein level).

DOI ID

10.1016/0014-5793(93)81336-x; 10.1038/361467a0; 10.1161/01.hyp.29.1.131; 10.1165/ajrcmb.20.5.3382; 10.1016/s0021-9258(19)51094-8; 10.1016/s0021-9258(18)99972-2; 10.1074/jbc.270.20.11735; 10.1093/emboj/16.5.899; 10.1093/emboj/16.21.6325; 10.1152/ajprenal.2001.280.6.f1093; 10.1038/87562; 10.1074/jbc.m110904200; 10.1016/s1631-0691(03)00154-9; 10.1007/s10735-018-9759-2

RefSeq

NP_113736.1